ZIF-8 induced hydroxyapatite-like crystals enabled superior osteogenic ability of MEW printing PCL scaffolds

ZIF-8 induced hydroxyapatite-like crystals enabled superior osteogenic ability of MEW printing PCL scaffolds

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Abstract ZIF-8 may experience ion-responsive degradation in ionic solutions, which will change its initial architecture and restrict its direct biological use.Herein, 100w products we report an abnormal phenomenon in which ZIF-8 induces large hydroxyapatite-like crystals when soaked directly in simulated body fluid.These crystals grew rapidly continuously for two weeks, with the volume increasing by over 10 folds.According to Zn2+ release and novel XRD diffraction peak presence, ZIF-8 particles can probably show gradual collapse and became congregate through re-nucleation and competitive coordination.

The phenomenon could be found on ZIF-8/PCL composite surface and printed ZIF-8/PCL scaffold surface.ZIF-8 enhanced PCL roughness through changing the surface topography, while obviously improving the in-vivo and in-vitro osteoinductivity and biocompatibility.The pro-biomineralization property can make ZIF-8 also applicable in polylactic acid-based biomaterials.In summary, this study demonstrates that ZIF-8 may play the role of a bioactive additive enabling the surface modification of synthetic polymers, iphone 13 dallas indicating that it can be applied in in-situ bone regeneration.